PX 12
PX-12
CAS: 141400-58-0
Molecular Formula: C7H12N2S2
PX 12 - Names and Identifiers
| Name | PX-12 |
| Synonyms | PX-12 PX 12 IV-2) CS-2384 PX-12 (PX12 2-(sec-Butyldisulfanyl)-1H-iMidazole 2-[(1-Methylpropyl)dithio]-1H-imidazole 1H-Imidazole, 2-[(1-methylpropyl)dithio]- |
| CAS | 141400-58-0 |
PX 12 - Physico-chemical Properties
| Molecular Formula | C7H12N2S2 |
| Molar Mass | 188.31 |
| Density | 1.19±0.1 g/cm3(Predicted) |
| Boling Point | 330.0±25.0 °C(Predicted) |
| Solubility | DMSO: ≥ 44.7 mg/mL |
| Appearance | powder |
| Color | off-white to tan |
| pKa | 11.88±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | In MCF-7 and HT-29 cells, PX-12 prevented the HIF-1alpha protein increase induced by hypoxia (1% oxygen) and decreased HIF-1 transactivation activity, VEGF formation, and inducible nitric oxide synthase. PX-12 also inhibited the growth of MCF-7 and HT-29 cells, with IC50s of 1.9 μm and 2.9 μm, respectively. PX-12 also inhibits HIF-1α protein levels through an increase mediated by Nrf2/PMF-1. In A549 cells, PX-12 inhibited cell growth by G2/M cell cycle arrest, and Bax-mediated, ROS-dependent apoptosis. In liver cancer cells, PX-12 and 5-FU play a synergistic effect, significantly inhibit Tumorigenicity. |
| In vivo study | PX-12 (12 mg/kg, I. p.) decreased HIF-1α and VEGF protein levels and microvessel density in mice bearing MCF-7 tumor xenografts. |
PX 12 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29332900 |
PX 12 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 5.31 ml | 26.551 ml | 53.103 ml |
| 5 mM | 1.062 ml | 5.31 ml | 10.621 ml |
| 10 mM | 0.531 ml | 2.655 ml | 5.31 ml |
| 5 mM | 0.106 ml | 0.531 ml | 1.062 ml |
Last Update：2024-01-02 23:10:35
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